鍦ㄦ姉鐧屾垬鍦烘姇涓嬧€滄櫤鑳藉埗瀵兼鍣ㄢ€?
銆€銆€鏈姤鍖椾含鐢碉紙鏉庨洦鏅达級杩戞棩锛岃В鏀惧啗鎬诲尰闄㈢浜斿尰瀛︿腑蹇冭娑茬梾鍖诲閮ㄩ珮鏅撳畞鏁欐巿鍥㈤槦鍜屽懆鏉版暀鎺堝洟闃熷悎浣滐紝鍦ㄥ浗闄呰憲鍚嶆湡鍒娿€奜ncogene銆嬪彂琛ㄧ獊鐮存€х爺绌舵垚鏋滐紝棣栨鎻ずPHF19鍩哄洜鍦ㄦ€ユ€ч珦绯荤櫧琛€鐥呬腑鐨勨€滆嚧鍛藉紑鍏斥€濅綔鐢紝涓虹牬瑙g櫧琛€鐥呭鍙戣€愯嵂闅鹃甯︽潵鍏ㄦ柊瑙e喅鏂规銆傝繖椤瑰彂鐜扮姽濡傚湪鎶楃檶鎴樺満鎶曚笅鈥滄櫤鑳藉埗瀵兼鍣ㄢ€濓紝鏈夋湜瀹炵幇鐧借鐥呯粏鑳炵殑绮惧噯鎵撳嚮銆?/p>
銆€銆€鎬ユ€ч珦绯荤櫧琛€鐥呬腑鐨則(8;21)浜氬瀷鎮h€呯害鍗犲叏閮ㄧ梾渚嬬殑15%銆傝繖绫绘偅鑰呰櫧鐒跺垵濮嬫不鐤楀弽搴旇緝濂斤紝浣嗙害40%浼氶伃閬囧鍙戞垨鑰愯嵂鍥板銆傚氨鍍忔垬鍦轰笂鐨勨€滈〗鍥哄垎瀛愨€濓紝杩欎簺鐧岀粏鑳炴€昏兘鎵惧埌閫冮€告不鐤楃殑鏆楅亾銆備紶缁熷寲鐤楀鍚屸€滃湴姣紡杞扮偢鈥濓紝鍦ㄦ潃浼ょ檶缁嗚優鐨勫悓鏃朵篃閲嶅垱姝e父缁嗚優锛屽鑷存不鐤楅櫡鍏ュ兊灞€銆傜爺绌跺洟闃熼攣瀹氱檶缁嗚優鈥滅敓鍛戒緵缁欑嚎鈥濓紝鍘嗘椂5骞存敾鍏筹紝鍙戠幇PHF19鍩哄洜寮傚父娲昏穬鐨勬偅鑰呮不鐤楁晥鏋滄樉钁楄緝宸€傞€氳繃鏋勫缓鍩哄洜缂栬緫灏忛紶妯″瀷璇佸疄锛氭姂鍒禤HF19鍩哄洜鍙娇鐧借鐥呯粏鑳炲娈栬兘鍔涗笅闄?0%锛屽疄楠屽皬榧犵敓瀛樻湡寤堕暱2.5鍊嶃€?/p>
銆€銆€鍥㈤槦棣栨闃愭槑WTAP-PHF19璋冩帶杞寸殑鍙岄噸琛ㄨ閬椾紶璋冩帶鏈哄埗锛岃繖鐩稿綋浜庢壘鍒颁簡鐧岀粏鑳炵殑鈥滆兘閲忔€绘帶寮€鍏斥€濄€備笉鍚屼簬浼犵粺鍩哄洜绐佸彉锛岃繖绉嶈〃瑙傞仐浼犳敼鍙樺叿鏈夊彲閫嗙壒鎬с€傞澏鍚戞姂鍒跺墏灏嗗儚鈥滄櫤鑳藉壀鍒€鈥濓紝绮惧噯鍓柇鐧岀粏鑳炵殑寮傚父淇″彿浼犲锛屾棦鑳介伩鍏嶁€滆浼も€濇甯哥粏鑳烇紝鍙堝彲闃叉鐧岀粏鑳炰骇鐢熻€愯嵂鎬с€傝繖绉嶆柊鍨嬫不鐤楃瓥鐣ョ獊鐮翠紶缁熷寲鐤楀眬闄愶紝閫氳繃璋冭妭鈥滃熀鍥犲紑鍏斥€濆疄鐜扮簿鍑嗘不鐤椼€傞殢鐫€鐩稿叧鑽墿鐮斿彂鎺ㄨ繘锛岄璁℃湭鏉?鈥?骞村唴鏈夋湜杩涘叆涓村簥璇曢獙闃舵锛屼负澶嶅彂闅炬不鎮h€呭甫鏉ユ洐鍏夈€?/p>